Synthesis of β-Lactams through Carbonylation of Diazo Compounds Followed by the [2 + 2] Cycloaddition Reaction
Fathima Febin Koothradan1, Arumugam Jayarani1, Chinnappan Sivasankar1
1Catalysis and Energy Laboratory, Department of Chemistry, Pondicherry University (A Central University), Puducherry605014, India.
Abstract:
Reporting an efficient method for the synthesis of β-lactams by the carbonylation of diazo compounds, using [Co2(CO)8] to corresponding ketenes, followed by [2 + 2] cycloaddition with imines. The newly developed strategy was successfully applied to electronically and structurally diverse substrates to produce the corresponding β-lactams under mild reaction conditions. Fourier transform infrared spectroscopy was employed to monitor ketene formation and the transformation of ketene into β-lactam. All the products were fully characterized by using various analytical and spectroscopic techniques.
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