Evaluation of hydroxamate-based resins towards a more clinically viable ⁴⁴Ti/⁴⁴Sc radionuclide generator

Several hydroxamate-based resins were synthesized and tested for use in ⁴⁴Ti/⁴⁴Sc generator systems in small scale experiments (740 kBq ⁴⁴Ti). The most promising resin was tested further in larger scale generator studies (37 MBq). This resin displayed impressive retention of ⁴⁴Ti over several elutions, and high quantities of ⁴⁴Sc were obtained in small volumes of dilute HCl eluents. Initial radiolabeling experiments were conducted and demonstrated the possibility of direct radiolabeling of the generator produced ⁴⁴Sc with DOTA.