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Cofilin 1 Is Dynamically Modulated During Postnatal Development and by Visual Input in the Mouse Visual Cortex.

Agustin Laguardia¹, Agustina Dapueto¹, Hanna McCuistion¹

¹Laboratorio de Neurociencias "Neuroplasticity Unit", Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay.

|December 5, 2022

Summary

Cofilin 1 protein levels decrease with age in the mouse visual cortex. Visual experience during development impacts cofilin 1 expression, suggesting its role in neural plasticity.

Keywords:

Cofilin 1 Visual cortex development monocular deprivation phospho-cofilin 1 plasticity

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Published on: February 21, 2021

Area of Science:

Neuroscience
Molecular Biology
Developmental Biology

Background:

Cofilin 1 is an actin-binding protein crucial for actin filament dynamics in dendritic spines.
Actin turnover in dendritic spines is essential for structural and functional neural plasticity.
Previous proteomic studies identified cofilin 1 as a potential regulator of plasticity in the mouse visual cortex.

Purpose of the Study:

To analyze cofilin 1 expression and its inactive phosphorylated form (phospho-cofilin 1) in the developing mouse visual cortex.
To investigate how visual input, specifically monocular deprivation, modulates cofilin 1 expression during critical developmental periods.

Main Methods:

Western blot analysis to quantify cofilin 1 and phospho-cofilin 1 levels.
Immunohistochemistry to visualize the spatial distribution of phospho-cofilin 1 in the visual cortex.
Monocular deprivation paradigm during postnatal development and adulthood.

Main Results:

Cofilin 1 levels decrease from the critical period to adulthood, correlating with reduced cortical plasticity.
Monocular deprivation increases cofilin 1 expression in the contralateral visual cortex during the critical period, but not in adults.
Phospho-cofilin 1 expression increases during postnatal development and is upregulated by monocular deprivation during the critical period.

Conclusions:

Cofilin 1 and its phosphorylation are dynamically regulated during visual cortex development.
These findings highlight the involvement of cofilin 1 in experience-dependent plasticity mechanisms in the visual cortex.
The regulation of cofilin 1 by visual input is specific to the critical developmental period.