Related Experiment Video
Updated: Aug 18, 2025

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
Two-handed facemask technique effectively causes hyperventilation in electroconvulsive therapy: an observational
Yoko Shimamoto1, Michiyoshi Sanuki2, Shigeaki Kurita2
1Department of Anesthesiology, NHO Kure Medical Center, 3-1 Aoyama, Kure, Hiroshima, Japan. shima@kyosai.or.jp.
The two-handed facemask technique for hyperventilation during electroconvulsive therapy (ECT) improves seizure quality and reduces cardiovascular stress. This method ensures better hypocapnia and inhaled minute ventilation compared to the one-handed technique.
Area of Science:
- Anesthesiology
- Psychiatry
- Neurology
Background:
- Electroconvulsive therapy (ECT) is a primary treatment for severe psychiatric conditions like depression.
- Hyperventilation during ECT can enhance seizure duration and quality, but efficient facemask techniques are crucial.
- Investigating optimal facemask ventilation is key to improving ECT protocols.
Purpose of the Study:
- To compare the efficacy of one-handed versus two-handed facemask techniques for hyperventilation in ECT.
- To evaluate the impact of these techniques on electroencephalogram (EEG) parameters and cardiovascular responses during ECT.
- To determine the optimal method for achieving adequate therapeutic seizures through controlled hyperventilation.
Main Methods:
- Sixty adult patients undergoing ECT were divided into two groups: one-handed (n=30) and two-handed (n=30) facemask ventilation.
- Hyperventilation was induced post-anesthesia, comparing manual bag ventilation (one-handed) with pressure-controlled ventilation (two-handed).
- EEG parameters, cardiovascular responses, and facemask leaks were monitored and compared between groups.
Main Results:
- The two-handed technique resulted in significantly less facemask leak (25.8 mL/breath vs. 201.7 mL/breath) and higher inhaled minute ventilation (11.95 L/min vs. 9.52 L/min).
- EEG regularity was better, and cardiovascular stress was minimized with the two-handed technique.
- The one-handed group showed lower SpO2 and greater ST-segment depression on ECG compared to the two-handed group.
Conclusions:
- The two-handed facemask technique, with pressure-controlled ventilation, is an effective method for hyperventilation in ECT, ensuring adequate therapeutic seizures.
- This technique reliably induces hypocapnia, as confirmed by end-tidal carbon dioxide monitoring.
- The two-handed approach did not increase cardiovascular stress compared to the one-handed method when adequate preoxygenation was provided.
Related Concept Videos
Electroconvulsive Therapy
Hyperpnea and Hyperventilation
Cardiopulmonary Resuscitation II: ACLS Airway Management
Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...

