Mussel-inspired polymer with catechol and cationic Lys functionalities for dentin wet bonding.

Area of Science:

• Biomaterials Science
• Adhesion Science
• Dental Materials

Background:

• Mussels exhibit remarkable adhesion in harsh aquatic environments.
• Achieving durable dentin bonds in wet conditions remains a challenge in dentistry.
• Water interferes significantly with current dentin bonding procedures.

Purpose of the Study:

• To synthesize a polymer mimicking mussel adhesion mechanisms for improved dentin bonding.
• To evaluate the efficacy of a catechol- and lysine-functionalized polymer (CLM) in wet dentin bonding.
• To enhance the stability and durability of the resin-dentin interface under wet conditions.

Main Methods:

• Synthesis of catechol-Lys-methacrylate (CLM) polymer.
• Application of CLM primer in an in vitro wet dentin-bonding model.
• Assessment of bond strength, durability, and interfacial interactions.

Main Results:

• CLM primer significantly improved bond strength and durability in wet dentin bonding.
• Lysine in CLM effectively repelled water from the demineralized dentin surface.
• Catechol groups facilitated numerous interfacial interactions, enhancing adhesion.
• Grafting CLM onto collagen improved its stability, enzymatic resistance, and adhesion.

Conclusions:

• The synthesized CLM polymer effectively replicates mussel-inspired adhesion strategies.
• CLM enhances wet dentin bonding by managing the hydration layer and promoting interfacial interactions.
• This catechol- and lysine-functionalized polymer offers a promising approach for stable resin-dentin interfaces.