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Accelerated Partial Breast Irradiation: Florence Phase 3 Trial Experience and Future Perspectives
Icro Meattini1,2, Kyubo Kim2,3, Lorenzo Livi1,2
1Department of Experimental and Clinical Biomedical Sciences "M. Serio," University of Florence.
American Journal of Clinical Oncology
|December 6, 2022
Summary
Accelerated partial breast irradiation (PBI) using a 5-fraction schedule demonstrates excellent long-term disease control and favorable outcomes. This approach represents a likely standard for postoperative PBI, balancing efficacy, safety, and quality of life.
Area of Science:
- Oncology
- Radiotherapy
- Clinical Trials
Background:
- Accelerated partial breast irradiation (PBI) is an evolving radiotherapy technique.
- Optimizing fractionation and delivery (preoperative vs. postoperative) remains an area of research.
Purpose of the Study:
- To report the experience and future perspectives of the Florence phase 3 trial on accelerated PBI.
- To compare intensity-modulated accelerated PBI with whole breast irradiation.
Main Methods:
- Single-center phase 3 trial.
- Comparison of intensity-modulated accelerated partial breast irradiation (30 Gy in 5 fractions) versus whole breast irradiation (50 Gy in 25 fractions) with a tumor bed boost (10 Gy in 5 fractions).
Main Results:
- Accelerated PBI demonstrated excellent long-term disease control.
- Favorable safety and cosmetic outcome profiles were observed with the accelerated PBI approach.
- A 5-fraction schedule appears to be an appropriate compromise for postoperative PBI.
Conclusions:
- The 5-fraction accelerated PBI regimen is effective and safe for postoperative treatment.
- Further research into preoperative PBI is warranted, addressing optimal dose and technique.
- A plateau in fraction reduction for postoperative PBI may have been reached.
