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Updated: Aug 18, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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National consensus on biologic dose reduction in psoriasis: a modified eDelphi procedure
L S van der Schoot1, E M Baerveldt2, W A van Enst3
1Department of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.
The Journal of Dermatological Treatment
|December 6, 2022
Summary
Consensus was reached on 15 recommendations for biologic dose reduction in psoriasis patients with stable disease. These criteria guide clinicians in consistent application of dose reduction strategies for better patient outcomes.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Biologic therapies are common for psoriasis, but guidelines for dose reduction are lacking.
- Clear criteria are needed for consistent biologic dose reduction in clinical practice.
Purpose of the Study:
- To establish consensus on criteria for biologic dose reduction in psoriasis patients with stable, low disease activity.
Main Methods:
- An online Delphi procedure (eDelphi) involving Dutch dermatologists was used.
- Consensus was defined as ≥70% agreement and <15% disagreement on proposed statements.
- Statements covered criteria for dose reduction and specific dosing schedules.
Main Results:
- 27 dermatologists reached consensus on 15 recommendations over two rounds.
- Criteria were established for dose reduction eligibility, continuation, and discontinuation.
- Dosing schedules for adalimumab, etanercept, and ustekinumab were agreed upon.
Conclusions:
- The consensus recommendations provide guidance for consistent biologic dose reduction in psoriasis management.
- An algorithm for clinical implementation was developed based on the eDelphi outcomes.
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