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Updated: Aug 18, 2025

Curtain Flow Column: Optimization of Efficiency and Sensitivity
Published on: June 12, 2016
Transport diameters of liquid chromatography columns
1Advachrom, P.O. Box 1243, Wilmington, DE 19801, USA.
Abstract:
The transport diameter (dM) of a chromatographic column is an objective (measurable) representation of cross-sectional dimensions of the column flow-through channels, and of the effect of porosity of the column internal support structure on velocity of transporting solvent molecules along the column. A column kinetic performance is trade-off between the column separation performance, analysis time and pressure. The dM is a key factor in definition of the kinetic performance factor - an objective metric of a column kinetic performance - and of other objective performance metrics. General equations for evaluation of dM are developed. The dM of PLOT, particulate and pillar-array columns are evaluated and discussed.
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