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Detection of interaction between an RNA aptamer and its target compound in living human cells using 2D in-cell NMR

Omar Eladl1,2,3, Yudai Yamaoki1,2, Keiko Kondo1

  • 1Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. katahira.masato.6u@kyoto-u.ac.jp.

Chemical Communications (Cambridge, England)
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Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
The...