Parental occupational exposures prior to conception and offspring wheeze and eczema during first year of life

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Felix Forster1, Christian Heumann2, Bianca Schaub3

  • 1Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.

Annals of Epidemiology
|December 8, 2022
PubMed

Insights

Parental occupational exposures to allergens and irritants before conception may increase offspring eczema risk. Reducing these exposures could protect children

Area of Science:

  • Environmental Health
  • Occupational Medicine
  • Pediatric Allergy

Background:

  • Parental pre-conception exposures may impact offspring asthma and allergy development.
  • Occupational exposures are known risk factors for adult asthma and allergies.

Purpose of the Study:

  • To investigate the association between parental occupational exposures before conception and the risk of wheeze and eczema in offspring during their first year of life.

Main Methods:

  • Analysis of 436 families from a German offspring cohort (2009-2019).
  • Occupational exposures assessed using Job-Exposure-Matrix based on work histories.
  • Bayesian logistic regression models employed for statistical analysis, with directed acyclic graphs for confounder selection.

Main Results:

  • Maternal occupational exposure to allergens before conception showed a suggestive association with offspring eczema (OR 1.22, 95% CI 0.92-1.57).
  • Maternal exposure to irritants prior to conception also suggested an increased risk of offspring eczema (OR 1.36, 95% CI 0.99-1.77).
  • No significant association was found between parental occupational exposures and offspring wheeze.

Conclusions:

  • Parental occupational exposures prior to conception may influence the risk of eczema in offspring.
  • Reducing occupational exposures could benefit both employees and their children by lowering the incidence of asthma and allergies.
Abstract

Keywords:
AsthmaDermatitis, atopicMaternal exposureOccupational exposurePaternal exposure

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