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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Applications Of NMR In Biology01:25

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
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Imaging Studies IV: Magnetic Resonance Imaging01:27

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

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Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
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Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
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Biological Magnetic Resonance Data Bank.

Jeffrey C Hoch1, Kumaran Baskaran1, Harrison Burr1

  • 1Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT 06030-3305, USA.

Nucleic Acids Research
|December 8, 2022
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Summary

The Biological Magnetic Resonance Data Bank (BMRB) is a key resource for biomolecular NMR data, supporting diverse research areas from structure to metabolomics. It is expanding due to technological advances and collaborations.

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Area of Science:

  • Biomolecular NMR Spectroscopy
  • Structural Biology
  • Biophysics
  • Metabolomics

Background:

  • The Biological Magnetic Resonance Data Bank (BMRB) serves as the international open data repository for biomolecular nuclear magnetic resonance (NMR) data.
  • BMRB archives both empirical and derived data crucial for understanding biomolecular structure, dynamics, and interactions.

Purpose of the Study:

  • To highlight the BMRB's role as a central resource for biomolecular NMR data.
  • To underscore the expanding applications of NMR data in biosciences, including drug discovery and metabolomics.
  • To emphasize BMRB's integration within global scientific infrastructure, such as the World-wide Protein Data Bank (wwPDB).

Main Methods:

  • Data curation and archiving of biomolecular NMR datasets.
  • Integration with advanced NMR instrumentation (GHz-class) and cyberinfrastructure.
  • Adoption of hybrid structural biology techniques and machine learning for data analysis.

Main Results:

  • BMRB provides a comprehensive repository supporting research in protein structure, dynamics, and interactions.
  • The bank facilitates studies on intrinsically disordered proteins, natural products, biomarkers, and metabolomics.
  • Technological advancements are significantly increasing the volume, variety, and utility of NMR data.

Conclusions:

  • BMRB is an essential, evolving resource for the global biosciences community.
  • Its role is amplified by cutting-edge NMR technology and data science approaches.
  • BMRB's status as a Core Archive within the wwPDB framework solidifies its importance.