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Updated: Aug 18, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Impact of radial compression protocols on radial artery occlusion and hemostasis time in coronary angiography
Sachiko Takamatsu1, Nobuyuki Kagiyama2,3, Naohiko Sone4
1Department of Nursing, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
Insights
A new radial compression protocol significantly reduces hemostasis time and radial artery occlusion after trans-radial approach (TRA) procedures. This optimized approach improves patient outcomes by minimizing complications and speeding recovery.
Area of Science:
- Cardiology
- Vascular Surgery
- Interventional Radiology
Background:
- Hemostasis protocols after trans-radial approach (TRA) lack standardization, leading to varied clinical practices.
- Current methods for achieving hemostasis post-TRA often result in prolonged compression times and potential complications.
Purpose of the Study:
- To evaluate the clinical implications of a novel, evidence-based radial compression protocol for hemostasis after TRA.
- To compare the efficacy and safety of the new protocol against traditional methods in an outpatient setting.
Main Methods:
- A comparative study involving 1842 patients undergoing invasive catheter angiography via TRA.
- Patients were divided into two groups: traditional (n=1001) and new (n=841) radial compression protocols.
- The new protocol involved air removal every 30 minutes, contrasting with the traditional protocol's fixed deflation times.
Main Results:
- The new protocol group demonstrated a significantly lower rate of dual antiplatelet therapy use (24% vs. 35%).
- Complete hemostasis time was reduced by approximately two-thirds with the new protocol (66 min vs. 190 min).
- Radial artery occlusion (RAO) incidence decreased dramatically from 9.8% in the traditional group to 0.9% in the new protocol group (p<0.001).
Conclusions:
- The new radial compression protocol significantly shortens hemostasis duration following TRA.
- This optimized protocol is strongly associated with a substantially lower incidence of radial artery occlusion.
- The findings support the adoption of this new protocol for improved patient safety and efficiency in TRA procedures.
Abstract:
Protocols for hemostasis after trans-radial approach (TRA) vary depending on the institute as there is no established evidence-based protocol. This study aimed to investigate the clinical implications of radial compression protocols. Consecutive patients who underwent outpatient invasive catheter angiography before and after April 2018 were treated with traditional and new protocols, respectively. Using the same hemostasis band, in the conventional protocol, fixed amount of air was removed soon after the procedure, 2 h later, and 3 h later, whereas the air was removed as much as possible every 30 min in the new protocol. A total of 1842 patients (71 ± 10 years old, 77% male) were included. Compared with the traditional protocol group (n = 1001), the new protocol group (n = 841) had a significantly lower rate of dual antiplatelet therapy (35% and 24% in the traditional and new groups, respectively, p < 0.001). The time required for complete hemostasis was approximately one-third with the new protocol (190 ± 16 and 66 ± 32 min, p < 0.001) with no clinically relevant bleeding. The incidence of radial artery occlusion (RAO) was 9.8% and 0.9% in the traditional and new protocol groups, respectively (p < 0.001). After adjusting for covariates, the new protocol was associated with a reduced risk of RAO (odds ratio 0.10, p < 0.001) and a shorter hemostasis time (odds ratio 0.01, p < 0.001). The new protocol for hemostasis after TRA was strongly associated with a shorter hemostasis time and a lower rate of RAO.
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