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Protective role of MG53 against ischemia/reperfusion injury on multiple organs: A narrative review
Bowen Xu1,2, Chunxiao Wang2, Hongping Chen2,3
1The 2nd Medical College of Binzhou Medical University, Yantai, Shandong, China.
Abstract:
Ischemia/reperfusion (I/R) injury is a common clinical problem after coronary angioplasty, cardiopulmonary resuscitation, and organ transplantation, which can lead to cell damage and death. Mitsugumin 53 (MG53), also known as Trim72, is a conservative member of the TRIM family and is highly expressed in mouse skeletal and cardiac muscle, with minimal amounts in humans. MG53 has been proven to be involved in repairing cell membrane damage. It has a protective effect on I/R injury in multiple oxygen-dependent organs, such as the heart, brain, lung, kidney, and liver. Recombinant human MG53 also plays a unique role in I/R, sepsis, and other aspects, which is expected to provide new ideas for related treatment. This article briefly reviews the pathophysiology of I/R injury and how MG53 mitigates multi-organ I/R injury.
Insights
Ischemia/reperfusion (I/R) injury causes cell damage, but Mitsugumin 53 (MG53) aids cell membrane repair. MG53 demonstrates protective effects against I/R injury in vital organs, offering new therapeutic avenues.
Area of Science:
- Biomedical science
- Cellular biology
- Pathophysiology
Background:
- Ischemia/reperfusion (I/R) injury is a significant clinical issue following procedures like angioplasty and organ transplantation.
- This injury can result in widespread cell damage and death across multiple organs.
- Mitsugumin 53 (MG53), also known as Trim72, is a protein involved in cell membrane repair.
Purpose of the Study:
- To review the pathophysiology of I/R injury.
- To explore the protective role of MG53 in mitigating multi-organ I/R injury.
- To highlight the therapeutic potential of MG53 in treating I/R-related conditions.
Main Methods:
- Literature review of existing studies on I/R injury.
- Analysis of MG53's function in cell membrane repair.
- Examination of MG53's effects on I/R injury in various organs.
Main Results:
- MG53 is highly expressed in muscle tissues and plays a crucial role in repairing damaged cell membranes.
- MG53 exhibits protective effects against I/R injury in organs including the heart, brain, lungs, kidneys, and liver.
- Recombinant human MG53 shows promise in addressing I/R injury and sepsis.
Conclusions:
- MG53 is a key factor in mitigating multi-organ I/R injury.
- The findings suggest MG53 as a potential therapeutic target for I/R-related conditions.
- Further research into MG53's mechanisms could lead to novel treatment strategies.
