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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Updated: Aug 18, 2025

Measuring Local Anaphylaxis in Mice
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An update on anaphylaxis and urticaria.

Margitta Worm1, Stefan Vieths2, Vera Mahler2

  • 1Division of Allergy and Immunology, Department of Dermatology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

The Journal of Allergy and Clinical Immunology
|December 8, 2022
PubMed
Summary

Recent advancements in anaphylaxis and urticaria research offer new insights into genetics, biomarkers, and mechanisms. Novel treatments and understanding of COVID-19

Keywords:
Anaphylaxisbiomarkerselicitorsgeneticsmechanismphenotypestreatmenturticaria

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Area of Science:

  • Immunology
  • Genetics
  • Dermatology

Background:

  • Anaphylaxis and urticaria are significant allergic conditions with complex underlying mechanisms.
  • Recent years have seen notable scientific progress in understanding these conditions.

Purpose of the Study:

  • To review recent scientific developments in anaphylaxis and urticaria.
  • To highlight advancements in genetics, biomarkers, mechanisms, and treatment approaches.

Main Methods:

  • Review of case-control studies, genome-wide association studies, and omics analyses.
  • Examination of new evidence on IgE-dependent and non-IgE-dependent pathways.
  • Analysis of COVID-19 pandemic's impact and vaccination-related anaphylaxis.

Main Results:

  • Enhanced understanding of genetic and biomarker profiles for anaphylaxis and urticaria.
  • Elucidation of signaling pathways, including Mas-related G protein-coupled receptor (MRGPR).
  • Identification of COVID-19 related triggers and pandemic impact on chronic urticaria management.

Conclusions:

  • Significant progress in understanding anaphylaxis and urticaria, including clinical grading and risk factors.
  • Novel therapeutic strategies show potential for improved disease control and prevention.
  • Further research into disease phenotypes and elicitors is ongoing.