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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Circulation of a single hepatitis A virus genotype IIIA with two distinct clusters in different states of India
Kavita S Lole1, Neeta C Thorat1, Prudhvi Lal Bhukya2
1Hepatitis Group, ICMR-National Institute of Virology, Pune, Maharashtra, India.
Abstract:
With the changing hepatitis A epidemiology in India, focal viral outbreaks are being reported from different parts of the country. This study presents Hepatitis A Virus (HAV) strain characterization (period 2009-2020) from 18 states of India. For that, blood and stool samples (n = 280) were screened for HAV RNA and sequences for 5'non-coding and VP3 regions were generated from positive samples (n = 68). Presence of a single IIIA genotype in all samples indicated IIIA being the only HAV genotype currently circulating in India. Interestingly, it was evident that these strains form two distinct groups suggesting independent evolution of these two clusters.

