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Chronic Rhinosinusitis in Patients with Primary Immunodeficiency
Ezgi Belhan Karadeniz1, Chinara Aliyeva2, Sezin Aydemir3
1Pediatrics, Istanbul University-Cerrahpasa, Istanbul, Turkey.
International Archives of Allergy and Immunology
|December 8, 2022
Summary
Chronic rhinosinusitis is prevalent in primary immunodeficiency patients, particularly those with a history of acute sinusitis. Further research is needed to understand the underlying mechanisms and improve treatment strategies for this vulnerable population.
Area of Science:
- Immunology
- Otolaryngology
- Infectious Diseases
Background:
- Primary immunodeficiencies (PIDs) are a diverse group of disorders increasing susceptibility to infections, autoimmunity, allergies, and cancer.
- Rhinosinusitis is a frequent infection observed in individuals with PIDs.
Purpose of the Study:
- To determine the prevalence of chronic rhinosinusitis (CRS) in patients with PIDs.
- To investigate the etiological factors contributing to CRS in this cohort.
Main Methods:
- Prospective enrollment of 44 PID patients (ages 4-26).
- Patient interviews for CRS symptoms, nasal endoscopic examinations.
- Retrospective review of medical records for laboratory tests, medications, allergy tests, and lung CT scans.
Main Results:
- No significant difference in CRS frequency was found across different PID types, atopy, hypogammaglobulinemia, or specific treatments.
- A statistically significant higher incidence of CRS (77.8%) was observed in patients with a history of acute sinusitis compared to those without (20%) (p=0.002).
Conclusions:
- Chronic rhinosinusitis is more common in patients with primary immunodeficiencies than in the general population.
- Identifying specific causative factors for CRS in PIDs is crucial for effective management.
- Larger studies are required to elucidate the mechanisms of CRS in PIDs.
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