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Systematic analysis of mistletoe prescriptions in clinical studies
Henrike Staupe1, Judith Buentzel2, Christian Keinki3
1Klinik Für Innere Medizin II, Hämatologie Und Onkologie, Universitätsklinikum Jena, Jena, Germany. h.staupe@web.de.
Journal of Cancer Research and Clinical Oncology
|December 9, 2022
Summary
This systematic review found no clear guidelines for using mistletoe therapy in cancer care. Mistletoe treatment lacks standardized protocols regarding preparation, dosage, and application for various cancer types.
Area of Science:
- Oncology
- Complementary and Alternative Medicine
- Systematic Review
Background:
- Mistletoe therapy is a controversial complementary treatment for cancer patients.
- Clinical studies on mistletoe treatment vary widely in their approach and outcomes.
Approach:
- A systematic search of multiple databases (Medline, Embase, CENTRAL, PsycINFO, CINAHL, Web of Science) was conducted from August to December 2020.
- 102 publications involving 19,441 patients were included, encompassing various study types and participant groups.
- Included studies investigated diverse mistletoe preparations, administration methods, and dosage schedules across different cancer types.
Key Points:
- The review included randomized controlled studies, cohort studies, and case reports.
- Commonly studied cancers included breast, pancreatic, colorectal, and malignant melanoma.
- Significant heterogeneity was observed in mistletoe extract types, host trees, administration routes, and dosage regimens.
Conclusions:
- No established relationship was found between specific mistletoe preparations, host trees, dosage, and cancer type.
- The research could not establish transparent rules or guidelines for mistletoe treatment in cancer care.
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