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Pulmonary Thromboembolism Developed During Hospitalization: A Nationwide Retrospective Observational Study Using
Miki Imura1, Tsunehisa Yamamoto2, Ken-Ichi Hiasa3
1Medical Affairs, Internal Medicine, Pfizer Biopharmaceuticals Group, Pfizer Japan Inc., 3-22-7, Yoyogi, Shibuya-Ku, Tokyo, 151-8589, Japan. miki.imura@pfizer.com.
Cardiology and Therapy
|December 9, 2022
Summary
The incidence of in-hospital pulmonary thromboembolism (PE) varies by clinical department and surgery status. Developing PE during hospitalization significantly increases hospital stay and mortality risk.
Area of Science:
- Medical research
- Clinical epidemiology
- Hospital-acquired conditions
Background:
- Unclear evidence on the incidence of pulmonary thromboembolism (PE) during hospitalization.
- Hypothesis that PE incidence varies by clinical department.
- Aim to survey in-hospital PE incidence.
Purpose of the Study:
- To determine the incidence of in-hospital PE.
- To analyze PE incidence based on clinical department and surgical status.
- To examine the impact of PE on hospital stay and mortality.
Main Methods:
- Retrospective analysis of Japanese claims data.
- Inclusion of in-hospital patients with and without PE.
- Analysis of PE incidence, prophylactic procedures, hospital stay, and mortality rates by department and surgery status.
Main Results:
- 5007 (0.107%) patients developed in-hospital PE, varying by department.
- PE incidence was 0.095% in non-surgical and 0.119% in surgical patients.
- PE onset correlated with prolonged hospital stay (31.0 vs 11.0 days) and higher mortality (11.0% vs 3.5%).
Conclusions:
- In-hospital PE incidence is influenced by patient characteristics, clinical departments, and surgery.
- PE during hospitalization significantly prolongs hospital stay and increases in-hospital mortality.
- Emphasizes the need for risk assessment and prophylactic measures upon admission.
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