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Incidence and Healthcare Resource Utilization Among Patients with Hypertrophic Cardiomyopathy Hospitalized for Heart
Yuika Ikeda1, Bruno Casaes Teixeira2, Thomas Laurent3
1Bristol Myers Squibb, Tokyo, Japan. yuika.ikeda@bms.com.
Insights
Heart failure (HF) hospitalization is a significant burden for patients with hypertrophic cardiomyopathy (HCM) in Japan. Atrial fibrillation, myocardial infarction, and prior HF were key predictors of HF hospitalization in this population.
Area of Science:
- Cardiology
- Public Health
Background:
- Heart failure (HF) is a common complication in hypertrophic cardiomyopathy (HCM) patients.
- Data on the burden of HCM and HF hospitalization in Japan are limited.
Purpose of the Study:
- To evaluate the burden of HF hospitalization in Japanese patients with HCM.
- To identify factors predisposing HCM patients to HF hospitalization.
Main Methods:
- Retrospective observational database study using a hospital-based claims database (2011-2023).
- Calculated incidence of first HF hospitalization post-HCM diagnosis.
- Nested case-control design to identify associated factors, costs, and outcomes.
Main Results:
- Incidence of HF hospitalization was 17.2 events/1000 patient-years.
- Patients hospitalized for HF had higher rates of comorbidities like atrial fibrillation (AF), myocardial infarction (MI), and prior HF.
- Predictors included AF, MI, HF, COPD, and loop diuretic use.
Conclusions:
- HF hospitalization represents a substantial clinical and economic burden for HCM patients.
- Identifying and managing comorbidities is crucial for reducing HF hospitalization rates in HCM.
Introduction:
Heart failure (HF) is one of the most common complications in patients with hypertrophic cardiomyopathy (HCM); however, there are limited data on HCM burden in Japan. We evaluated the burden of HF hospitalization and factors that predispose patients with HCM to HF hospitalization.
Methods:
This retrospective observational database study used a hospital-based claims database from January 01, 2011, to December 31, 2023, provided by Medical Data Vision Co., Ltd. The primary objective of the study was to calculate the incidence of first HF hospitalization after HCM diagnosis. A nested case-control design compared patients with or without hospitalization to identify factors associated with HF hospitalization. Hospitalization costs and outcomes after discharge were also described.
Results:
Of 12,145 patients with newly diagnosed HCM without HF hospitalization, 525 were hospitalized with HF during the follow-up period. The mean age ± standard deviation (SD) of the overall study population at cohort entry date was 71.4 ± 14.0 years, and 45.8% were female patients. The incidence of HF hospitalization was 17.2 events/1000 patient-years. Patients with HCM hospitalized for HF had higher rates of comorbidities, including HF (45.9%), diabetes mellitus (28.6%), hypertension (23.0%), atrial fibrillation (AF; 21.3%), myocardial infarction (MI; 17.5%), arrhythmia except AF (15.0%), and dyslipidemia (13.1%), than patients without HF hospitalization. Significant predictors of hospitalization among patients with HCM were AF (odds ratio [OR] 1.63; 95% confidence interval [CI] 1.18-2.25; p = 0.003), MI (OR 1.68; 95% CI 1.20-2.35; p = 0.003), HF (OR 1.82; 95% CI 1.39-2.39; p < 0.001), chronic obstructive pulmonary disease (OR 2.30; 95% CI 1.08-4.89; p = 0.031), and loop diuretics (OR 4.35; 95% CI 3.33-5.69; p < 0.001). The average costs, length of hospital stay, and overall mortality rate associated with HF hospitalization were 1035 kJPY (~ 156,750 USD), 20.0 days, and 8.8%, respectively.
Conclusions:
HF hospitalization in patients with HCM imposes a significant clinical and economic burden.
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