Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

236
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
236
Ventilatory Modes01:14

Ventilatory Modes

332
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
332
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

835
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
835
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

202
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
202
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

54
Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
54
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

772
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
772

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Safety/Therapeutic Results of ALT-100 eNAMPT mAb Impact in the PUERTA Phase 2A ARDS Trial.

American journal of respiratory and critical care medicine·2026
Same author

Institutional Variation in Life-Sustaining Treatments and Mortality Among Older Patients.

JAMA health forum·2026
Same author

Association between ICU-level variation in arterial blood gas utilization and in-hospital mortality: A retrospective cohort study using the Japanese Intensive care PAtient Database registry.

PloS one·2026
Same author

Operational Integration and Temporal Validation of a Continuously Deployed ICU Prediction Model.

Critical care medicine·2026
Same author

Different longitudinal patterns of sequential organ failure assessment (SOFA) and SOFA-2 scores during extracorporeal membrane oxygenation and continuous renal replacement therapy in septic cardiomyopathy.

Journal of anesthesia·2026
Same author

Alarms in Long-Term Home Mechanical Ventilation.

Respiratory care·2026
Same journal

Cardiogenic shock - toward phenotype-directed, precision management.

Current opinion in critical care·2026
Same journal

The future of critical care nutrition: from calorie counting to precision personalized metabolism therapy.

Current opinion in critical care·2026
Same journal

Editorial introduction.

Current opinion in critical care·2026
Same journal

Generative artificial intelligence for outcome prediction in critical care: the future is now?

Current opinion in critical care·2026
Same journal

Feeding under support in critical care illness: metabolic and nutritional management during extracorporeal membrane oxygenation and continuous renal replacement therapy.

Current opinion in critical care·2026
Same journal

Multinational collaborations in critical care research: feasible and useful?

Current opinion in critical care·2026
See all related articles

Related Experiment Video

Updated: Aug 18, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.2K

Closed-loop ventilation.

Jean-Michel Arnal1,2, Shinshu Katayama3, Christopher Howard4

  • 1Service de réanimation polyvalente, Hôpital Sainte Musse, Toulon, France.

Current Opinion in Critical Care
|December 9, 2022
PubMed
Summary
This summary is machine-generated.

Closed-loop ventilation modes offer benefits for patients and intensive care units (ICUs) by improving oxygenation, lung protection, and weaning. Further research is needed to confirm their impact on clinical outcomes and cost-effectiveness.

More Related Videos

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

1.5K
Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model
07:56

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

Published on: May 18, 2021

3.7K

Related Experiment Videos

Last Updated: Aug 18, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.2K
Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

1.5K
Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model
07:56

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

Published on: May 18, 2021

3.7K

Area of Science:

  • Critical Care Medicine
  • Respiratory Therapy
  • Biomedical Engineering

Background:

  • Closed-loop ventilation modes have seen significant development over the past 25 years, with several commercially available options.
  • These advanced modes aim to address challenges in the Intensive Care Unit (ICU), including caregiver shortages and high bedside workload.
  • This review focuses on the clinical advantages of closed-loop ventilation in oxygenation control, lung protection, and patient weaning.

Approach:

  • Review of current literature on closed-loop ventilation systems.
  • Analysis of physiological variables controlled by closed-loop modes, such as oxygen saturation, tidal volume, driving pressure, and mechanical power.
  • Evaluation of the adaptive capabilities of these modes in supporting patient needs and diaphragm activity.

Key Points:

  • Closed-loop ventilation modes maintain physiological variables within target ranges for continuous lung protection.
  • These systems adapt ventilator support to individual patient requirements, promoting diaphragm function and preventing over-assistance.
  • Studies suggest potential reductions in the duration of mechanical ventilation and weaning periods.

Conclusions:

  • Recent studies highlight the safety, efficacy, and feasibility of closed-loop ventilation in ICU and postsurgical patients.
  • Larger, multicenter randomized controlled trials are necessary to fully evaluate their impact on clinical outcomes, ICU organization, and cost-effectiveness.