Related Experiment Video
Updated: Aug 18, 2025
06:38
In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
Published on: March 7, 2025
580
Early developmental profiles among infants with Down syndrome
S Onnivello1, E K Schworer2, M A Prince3
1Department of Developmental Psychology and Socialization, University of Padova, Padova, Italy.
Journal of Intellectual Disability Research : JIDR
|December 9, 2022
Summary
Infants with Down syndrome (DS) show varied developmental paths. This study identified three distinct early developmental profiles in DS infants, aiding early intervention strategies.
Area of Science:
- Developmental Psychology
- Pediatrics
- Genetics
Background:
- Down syndrome (DS) is associated with developmental differences, but significant heterogeneity exists within the syndrome.
- Understanding early developmental variations in infants with DS is crucial for targeted support.
Purpose of the Study:
- To investigate the presence of distinct developmental profiles in infants with Down syndrome.
- To identify factors associated with different developmental trajectories in early childhood.
Main Methods:
- Bayley Scales of Infant Development III (Bayley-III) administered to 75 infants with DS (age 3.9-17.6 months).
- Latent profile analysis used to identify developmental patterns across five domains.
- Caregiver-reported developmental history and demographics collected.
Main Results:
- Three distinct developmental profiles were identified: Mild Delay, Moderate Delay, and Pronounced Delay.
- Chronological age, prior heart surgery, and occupational therapy were linked to profile membership.
Conclusions:
- Early infancy reveals heterogeneous developmental presentations in Down syndrome.
- These findings support personalized early intervention planning for infants with DS.
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