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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
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Leveraging Tissue Engineering for Skin Cancer Models.

Sumayah Oudda1, Abdulla M Ali2, Anna L Chien3

  • 1Department of Biology, Johns Hopkins University, Baltimore, MD, USA.

Advances in Experimental Medicine and Biology
|December 9, 2022
PubMed
Summary

This study reviews bioengineered three-dimensional (3D) skin cancer models, highlighting their potential for preclinical testing. It discusses limitations and future directions for developing more comprehensive models for melanoma, basal cell carcinoma, and squamous cell carcinoma.

Keywords:
Basal cell carcinoma (BCC)In vitro 3D modelMelanomaSkin cancerSquamous cell carcinoma (SCC)

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Area of Science:

  • Biotechnology
  • Oncology
  • Dermatology

Background:

  • Bioengineered three-dimensional (3D) skin models offer a promising platform for studying skin cancer.
  • Current models often lack full-thickness complexity, omitting crucial dermal and hypodermal layers.
  • A comprehensive 3D skin model is vital for understanding human physiology and cancer biology.

Purpose of the Study:

  • To summarize existing skin cancer models, detailing their components and fabrication.
  • To analyze models for melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC).
  • To identify current limitations and future research directions in skin cancer modeling.

Main Methods:

  • Review of literature on bioengineered 3D skin cancer models.
  • Analysis of models based on skin layers, materials, cell lines, treatments, and fabrication techniques.
  • Categorization of models for melanoma, BCC, and SCC.

Main Results:

  • Various 3D skin models utilize different skin layers, biomaterials, and cell lines.
  • Specific treatments and fabrication techniques are employed for modeling melanoma, BCC, and SCC.
  • A gap exists in the development of full-thickness 3D skin models.

Conclusions:

  • Understanding the current state of skin cancer models is crucial for advancing cancer research.
  • Improved 3D skin models can lead to more effective preclinical testing and cancer treatments.
  • Further development is needed for comprehensive, full-thickness 3D skin models.