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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
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Comparison Between Numeric Parameters From Acute and Chronic Venous Leg Ulcers: Identification of Potential Objective
Nicolas A Cerusico1, Romina Chavez-Jara2, Silvana A Lopez2
1Instituto de Biotecnología Farmacéutica y Alimentaria (INBIOFAL-CONICET), San Miguel de Tucumán, Argentina.
Wound Management & Prevention
|December 9, 2022
Summary
Objective parameters are needed to assess chronic venous leg ulcers (CVLU). This study compared numeric data from acute and chronic ulcers to find potential nonhealing markers, aiming for better monitoring and treatment of CVLU.
Area of Science:
- Wound healing research
- Biomedical engineering
- Clinical diagnostics
Background:
- Clinical assessment of chronic venous leg ulcers (CVLU) often relies on subjective interpretation, leading to suboptimal treatment and high recurrence.
- Objective, measurable parameters are crucial for accurate CVLU assessment and management.
Purpose of the Study:
- To compare numeric parameters between acute and chronic venous leg ulcers.
- To identify objective nonhealing parameters for CVLU.
Main Methods:
- Collected data on exudate pH, lactate, glucose, temperature variations, microbiology, and imaging from hospital outpatients (2016-2019).
- Established cohorts based on ulcer evolution time.
Main Results:
- 83% of ulcers were chronic; 71% of CVLUs and 59% of acute ulcers had pH ≥8.
- Temperature variations (ΔT1, ΔT2) above 1 may indicate inflammation.
- All acute and 88% of CVLUs showed <80% granulation tissue; all samples had >105 organisms/gram tissue.
Conclusions:
- No significant differences in currently measured clinical parameters between acute and chronic ulcers.
- Further research is needed to establish objective cutoff points for differentiating chronic/nonhealing ulcers.
- Easily obtainable, low-cost nonhealing parameters could offer a new approach for monitoring CVLU.
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