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Updated: Aug 18, 2025

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
Cellular mechanisms in brain aging: Focus on physiological and pathological aging
Leonardo Aguilar-Hernández1, Ricardo Alejandre2, Julio César Morales-Medina3
1Lab. Neuropsiquiatría, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, San Manuel 72570, Puebla, Mexico; Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico.
Aging involves cellular damage, oxidative stress, and inflammation, particularly in the brain, leading to cognitive decline. Antioxidant and anti-inflammatory supplements may help mitigate these aging effects and improve quality of life.
Area of Science:
- Gerontology and Neuroscience
- Cellular Biology and Aging Research
Background:
- Aging is characterized by accumulating cellular damage, including oxidative stress, senescence, inflammation, and DNA damage.
- These processes impact high metabolic rate tissues like the brain, leading to atrophy in regions vital for cognitive functions (memory, learning).
- Cognitive decline is observed in physiological aging and worsened in pathological aging.
Purpose of the Study:
- To review cellular processes underlying aging triggers and their interrelations.
- To identify the central factor initiating cellular aging processes.
- To differentiate between normal and pathological aging and explore therapeutic interventions.
Main Methods:
- Literature review of cellular aging mechanisms.
- Analysis of the interplay between oxidative stress, inflammation, and cognitive decline.
- Evaluation of antioxidant and anti-inflammatory supplement efficacy.
Main Results:
- Oxidative stress and cellular damage are key contributors to physiological brain atrophy during aging.
- Supplements with antioxidant and anti-inflammatory properties show potential in reducing age-related cognitive decline.
- These findings support the role of cellular damage in aging and suggest therapeutic avenues.
Conclusions:
- Cellular damage, driven by oxidative stress and inflammation, is central to aging-related cognitive decline.
- Targeting these pathways with supplements may offer therapeutic benefits for the aging population.
- Further research into supplements could enhance the quality of life for aging individuals.
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