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Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks
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LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator
Elke Butt1, Cory M Howard2, Dayanidhi Raman2
1Institute of Experimental Biochemistry II, University Clinic Wuerzburg, 97080 Wuerzburg, Germany.
Cells
|December 11, 2022
Summary
LIM and SH3 protein 1 (LASP1) is a cytoskeletal protein with emerging roles in cancer cell signaling and gene expression. This review details how LASP1 phosphorylation drives tumor progression and metastasis through various cellular pathways.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- LIM and SH3 protein 1 (LASP1) was initially recognized for its structural and scaffolding functions within the cytoskeleton.
- Emerging evidence highlights LASP1's significant roles in cellular signaling and gene expression, particularly within tumor cells.
Purpose of the Study:
- To review the phosphorylation-dependent interactions of LASP1 that regulate tumor progression and metastasis.
- To elucidate the specific roles of LASP1 in chemokine receptor signaling, PI3K/AKT pathways, and nuclear functions including epigenetics and mRNA translation.
Main Methods:
- Literature review focusing on phosphorylation-dependent interactions of LASP1.
- Analysis of studies investigating LASP1's involvement in cancer signaling pathways.
- Examination of research on LASP1's nuclear functions and cytoskeletal roles.
Main Results:
- LASP1 phosphorylation is a key regulator of its novel functions in cancer.
- LASP1 influences tumor progression and metastasis via chemokine receptor and PI3K/AKT signaling pathways.
- LASP1 plays roles in epigenetic regulation, transcriptional control, and oncogenic mRNA translation, in addition to its F-actin binding properties.
Conclusions:
- LASP1 is a multifunctional protein critical for tumor progression and metastasis.
- Understanding LASP1's phosphorylation-dependent interactions provides insights into novel therapeutic strategies for cancer.
- LASP1's diverse roles, from cytoskeletal organization to gene regulation, underscore its importance in oncology.
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