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Updated: Aug 18, 2025

Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks
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Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks

Published on: December 24, 2016

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LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator

Elke Butt1, Cory M Howard2, Dayanidhi Raman2

  • 1Institute of Experimental Biochemistry II, University Clinic Wuerzburg, 97080 Wuerzburg, Germany.

Cells
|December 11, 2022
PubMed

Insights

LIM and SH3 protein 1 (LASP1) is a cytoskeletal protein with emerging roles in cancer cell signaling and gene expression. This review details how LASP1 phosphorylation drives tumor progression and metastasis through various cellular pathways.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • LIM and SH3 protein 1 (LASP1) was initially recognized for its structural and scaffolding functions within the cytoskeleton.
  • Emerging evidence highlights LASP1's significant roles in cellular signaling and gene expression, particularly within tumor cells.

Purpose of the Study:

  • To review the phosphorylation-dependent interactions of LASP1 that regulate tumor progression and metastasis.
  • To elucidate the specific roles of LASP1 in chemokine receptor signaling, PI3K/AKT pathways, and nuclear functions including epigenetics and mRNA translation.

Main Methods:

  • Literature review focusing on phosphorylation-dependent interactions of LASP1.
  • Analysis of studies investigating LASP1's involvement in cancer signaling pathways.
  • Examination of research on LASP1's nuclear functions and cytoskeletal roles.

Main Results:

  • LASP1 phosphorylation is a key regulator of its novel functions in cancer.
  • LASP1 influences tumor progression and metastasis via chemokine receptor and PI3K/AKT signaling pathways.
  • LASP1 plays roles in epigenetic regulation, transcriptional control, and oncogenic mRNA translation, in addition to its F-actin binding properties.

Conclusions:

  • LASP1 is a multifunctional protein critical for tumor progression and metastasis.
  • Understanding LASP1's phosphorylation-dependent interactions provides insights into novel therapeutic strategies for cancer.
  • LASP1's diverse roles, from cytoskeletal organization to gene regulation, underscore its importance in oncology.
Keywords:
AKTCXCR4LASP1cytoskeletonepigeneticsnucleusphosphorylationstructuretranscriptional regulation

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