Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

21.5K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.5K
Metastasis02:30

Metastasis

5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

14.8K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
14.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct imaging-based gradient metasurface sensor enabling spectrometer-free ultrasensitive biomolecule detection.

Nature communications·2026
Same author

Oxidative aging facilitates biological barrier penetration of polyethylene microplastics, amplifying systemic lipotoxicity in aquatic species.

Particle and fibre toxicology·2026
Same author

Wafer-level meta-aspheric lenses for compact wide-FOV NIR imaging.

Light, science & applications·2026
Same author

Extending the boundaries of ultraviolet-visible meta-optics via direct imprinting of tantalum pentoxide composite.

Microsystems & nanoengineering·2026
Same author

Oxidative stress-induced astrocytic collagen biosynthesis drives glial barrier formation and neuronal death in ischemic stroke.

Cell metabolism·2026
Same author

Intralesional Adipose-Derived Stem Cells Reverse Established Dermal Fibrosis and Modulate Angiogenesis-Related Readouts in a Murine Systemic Sclerosis Model.

Tissue engineering and regenerative medicine·2026

Related Experiment Video

Updated: Aug 18, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K

MicroRNA-Gene Interactions Impacted by Toxic Metal(oid)s during EMT and Carcinogenesis.

Franklin Tran1, Eunji Lee1, Suresh Cuddapah1

  • 1Division of Environmental Medicine, Department of Medicine, Grossman School of Medicine, New York University, New York, NY 10010, USA.

Cancers
|December 11, 2022
PubMed
Summary

Toxic metal(loid)s exposure disrupts microRNA (miRNA) regulation of epithelial-mesenchymal transition (EMT), a key process in cancer metastasis. Understanding these chemical-miRNA-gene interactions offers potential for new cancer biomarkers and therapies.

Keywords:
EMTarseniccadmiumcarcinogenesischromiummetalsmicroRNAsnickel

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.5K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.8K

Related Experiment Videos

Last Updated: Aug 18, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.5K
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.5K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.8K

Area of Science:

  • Environmental Health
  • Molecular Biology
  • Cancer Research

Background:

  • Chronic exposure to toxic metal(loid)s is a significant factor in human cancer development.
  • Cancer metastasis, responsible for 90% of cancer deaths, is initiated by epithelial-mesenchymal transition (EMT).
  • MicroRNAs (miRNAs) are crucial regulators of genes involved in EMT and cancer progression.

Purpose of the Study:

  • To review recent findings on how toxic metal(loid)s affect miRNA expression.
  • To elucidate the chemical-miRNA-gene interactions that perturb EMT.
  • To highlight the potential of miRNAs as biomarkers and therapeutic targets in metal(loid)-induced cancers.

Main Methods:

  • Literature review of mechanistic studies on toxic metal(loid)s, miRNAs, and EMT.
  • Focus on interactions involving arsenic, cadmium, nickel, and chromium.
  • Analysis of how altered miRNA expression impacts cancer signaling pathways.

Main Results:

  • Toxic metal(loid)s alter the expression of specific miRNAs that regulate EMT-associated genes.
  • These alterations in miRNA expression are linked to cancer development and metastasis.
  • Identified chemical-miRNA-gene interactions provide insights into carcinogenesis.

Conclusions:

  • Altered miRNA expression due to toxic metal(loid) exposure can serve as predictive biomarkers for cancer survival and treatment response.
  • miRNAs represent promising therapeutic targets for mitigating the effects of toxic metal(loid)s in cancer.
  • Further research into these interactions is crucial for developing novel cancer prevention and treatment strategies.