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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Long Intergenic Non-Protein Coding RNA 173 in Human Cancers.

Wei Mao1, Yi Liao2, Liling Tang1

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Long non-coding RNAs (lncRNAs), like LINC00173, are implicated in cancer development. This review highlights LINC00173

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators in cellular processes.
  • Dysregulation of lncRNAs is increasingly linked to complex diseases, particularly cancer.
  • LINC00173 is a recently identified lncRNA with emerging roles in human malignancies.

Purpose of the Study:

  • To review and summarize current research on LINC00173 in human cancers.
  • To elucidate the aberrant expression patterns and molecular mechanisms of LINC00173 in tumorigenesis.
  • To explore the potential of LINC00173 as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Comprehensive literature search on LINC00173 and cancer.
  • Analysis of studies reporting LINC00173 expression in various cancer types.
  • Synthesis of data on LINC00173's molecular functions and regulatory pathways in cancer.

Main Results:

  • LINC00173 exhibits aberrant expression across 11 different human cancers.
  • Evidence suggests LINC00173 influences cancer initiation and progression through specific molecular mechanisms.
  • The review consolidates findings on LINC00173's involvement in diverse oncogenic pathways.

Conclusions:

  • LINC00173 plays a significant role in the development and progression of multiple human cancers.
  • LINC00173 demonstrates potential as a valuable diagnostic biomarker for cancer detection.
  • Targeting LINC00173 may offer a novel therapeutic strategy for cancer treatment.