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Myocarditis Related to COVID-19 and SARS-CoV-2 Vaccination

Ana I Molina-Ramos1,2, Elisabeth Gómez-Moyano3, Jorge Rodríguez-Capitán1,2

  • 1Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Cardiology Department, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.

Journal of Clinical Medicine
|December 11, 2022
PubMed

Insights

Myocarditis, a heart condition, can be a consequence of COVID-19 and mRNA vaccines. This review examines its epidemiology and prognosis, balancing risks against vaccination benefits.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • Coronavirus disease 2019 (COVID-19) has caused significant global morbidity and mortality.
  • Myocarditis, a heart inflammation, is a notable consequence of COVID-19 with potentially poor prognosis.
  • The epidemiology and specific prognosis of COVID-19-related myocarditis remain largely unknown.

Purpose of the Study:

  • To review the etiopathogenesis, epidemiology, clinical features, diagnosis, prognosis, and treatment of myocarditis associated with SARS-CoV-2 infection.
  • To analyze myocarditis occurring secondary to COVID-19 mRNA vaccination.
  • To contextualize myocarditis risk within the overall public health benefits of COVID-19 vaccination.

Main Methods:

  • This study is a narrative review.
  • Literature search on SARS-CoV-2, COVID-19, myocarditis, and mRNA vaccines.
  • Synthesis of existing data on the topic.

Main Results:

  • Myocarditis is a recognized complication of COVID-19.
  • Myocarditis is also a rare adverse event associated with mRNA COVID-19 vaccines.
  • Data on the specific epidemiology and long-term prognosis of COVID-19-related myocarditis is still emerging.

Conclusions:

  • Myocarditis requires consideration as a potential consequence of both COVID-19 and its vaccination.
  • The benefits of COVID-19 vaccination are substantial and should be weighed against the rare risk of myocarditis.
  • Further research is needed to fully elucidate the epidemiology and prognosis of COVID-19-associated myocarditis.

Keywords:
COVID-19mRNA vaccinesmyocarditis

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