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Related Experiment Video

Updated: Aug 18, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

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Left Ventricular Diastolic Function in Subjects Conceived through Assisted Reproductive Technologies.

Franziska Sciuk¹, Theresa Vilsmaier², Marie Kramer¹

¹Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, Marchioninistraße 15, 81377 Munich, Germany.

Journal of Clinical Medicine

|December 11, 2022

Summary

This summary is machine-generated.

Children conceived via assisted reproductive technologies (ART) may have impaired heart function. This study found lower left ventricular (LV) diastolic function in ART subjects, particularly those born preterm, suggesting a need for echocardiographic monitoring.

Keywords:

assisted reproductive technologies cardiac function echocardiography left ventricular diastolic function pediatrics

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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Area of Science:

Cardiology
Pediatrics
Reproductive Medicine

Background:

Assisted reproductive technologies (ART) may impact cardiovascular health.
Premature vascular aging is a potential concern for ART-conceived individuals.
Left ventricular (LV) diastolic function is a key indicator of cardiac health.

Purpose of the Study:

To investigate subtle differences in LV diastolic function between young ART subjects and spontaneously conceived peers.
To utilize echocardiography to assess LV diastolic parameters in these groups.
To identify potential early signs of cardiovascular alterations in ART-conceived children.

Main Methods:

Echocardiographic assessment of LV dimensions and mitral inflow velocities.
Measurement of myocardial early diastolic velocity (E') at the LV wall and interventricular septum (IVS).
Calculation of average E/E' (E/E'AVG) and comparison between ART subjects (n=66) and controls (n=83).

Main Results:

ART subjects exhibited significantly lower E'LV compared to controls (p=0.020).
ART participants aged ≥10 years showed significantly higher E/E'AVG (p=0.035).
Adjusted analyses revealed no significant differences in LV diastolic function between groups.

Conclusions:

ART subjects demonstrate reduced LV diastolic function compared to spontaneously conceived peers.
Preterm ART-born individuals may be at higher risk for LV diastolic alterations.
Regular echocardiographic monitoring is recommended for preterm ART-conceived children.