Salivary Biomarkers in Periodontitis Post Scaling and Root Planing

Area of Science:

• Oral Medicine
• Periodontology
• Biochemistry

Background:

• Periodontitis and gingivitis are inflammatory conditions affecting periodontal tissues.
• Salivary biomarkers are increasingly utilized for non-invasive disease assessment.

Purpose of the Study:

• To evaluate salivary uric acid and arginase levels in periodontitis, gingivitis, and healthy individuals.
• To investigate the impact of non-surgical periodontal therapy on these salivary markers.

Main Methods:

• Sixty subjects were categorized into healthy, generalized gingivitis, and generalized periodontitis groups.
• Saliva samples and periodontal parameters were assessed at baseline and post-therapy (day 90).
• Non-surgical periodontal therapy was administered to gingivitis and periodontitis groups.

Main Results:

• Salivary arginase levels were elevated in gingivitis and periodontitis groups at baseline.
• Salivary uric acid levels were lower in gingivitis and periodontitis groups at baseline.
• Both markers showed significant changes post-therapy, correlating with clinical improvements.

Conclusions:

• Salivary arginase acts as a pro-inflammatory marker in periodontal disease.
• Elevated salivary uric acid levels indicate an anti-inflammatory role following periodontal therapy.
• These salivary markers are valuable for assessing periodontal status and treatment outcomes.