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Gut microbiota imbalance (dysbiosis) is linked to colon diverticulosis and diverticular disease (DD). This review explores this connection and the potential of probiotics for managing DD.

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Area of Science:

  • Gastroenterology and Microbiology
  • Focuses on the gut microbiome's role in digestive health and disease.

Background:

  • Gut microbiota (GM) dysbiosis is implicated in various diseases, particularly gastrointestinal disorders.
  • Colon diverticulosis and diverticular disease (DD) are prevalent digestive conditions.
  • Emerging research suggests a link between GM imbalance and the clinical spectrum of DD.

Purpose of the Study:

  • To review and critically analyze current knowledge on gut microbiota dysbiosis in diverticulosis and DD.
  • To compare GM data in DD with findings from inflammatory bowel disease (IBD).
  • To discuss the rationale for using probiotics to address dysbiosis in DD.

Main Methods:

  • Narrative review of existing scientific literature.
  • Critical analysis of studies on gut microbiota in diverticulosis and DD.
  • Comparative analysis with data from inflammatory bowel disease research.

Main Results:

  • Highlights the significant role of gut microbiota imbalance in the pathogenesis of diverticulosis and DD.
  • Compares the patterns of dysbiosis observed in DD with those in IBD, identifying similarities and differences.
  • Identifies a potential therapeutic strategy involving probiotics for restoring gut microbial balance in DD.

Conclusions:

  • Gut microbiota dysbiosis is a key factor in the development and manifestation of diverticular disease.
  • Probiotics show promise as a therapeutic intervention for rebalancing the gut microbiome in DD patients.
  • Further research is warranted to fully elucidate the GM-DD relationship and optimize probiotic strategies.