Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inflammatory nodule after hyaluronic acid and hyaluronidase injection at ultra-high-frequency ultrasound.

Medical ultrasonography·2026

Same author

Allosteric Activation of GDH/TCA Pathway Reduces Pathological Build-Up and Promotes Neuronal Survival in an In Vitro Model of Alzheimer's Disease.

Biomolecules·2026

Same author

The Oxidative Stress Imbalance in Children and Adults with IBD and Associated Factors.

Nutrients·2026

Same author

Advances in pharmacological treatment and management of hyperhidrosis.

Expert opinion on pharmacotherapy·2026

Same author

TROP-2 Is Not a Therapeutic Target in Melanoma: a Morphological Study.

Dermatology and therapy·2026

Same author

Real-World Efficacy of IL-23 Inhibitors in Psoriasis Affecting High-Impact Areas: Indirect Comparison of Tildrakizumab 200 mg, Risankizumab, and Guselkumab-IL PSO (Italian Landscape Psoriasis).

Dermatology and therapy·2026

Search research articles

Related Experiment Video

Updated: Aug 18, 2025

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

Mesenchymal Stem Cells and Psoriasis: Systematic Review.

Federico Diotallevi¹, Mariangela Di Vincenzo², Emanuela Martina¹

¹Department of Clinical and Molecular Sciences, Dermatological Clinic, Università Politecnica delle Marche, 60126 Ancona, Italy.

International Journal of Molecular Sciences

|December 11, 2022

Summary

Mesenchymal stem cells (MSCs) interact with inflammatory environments, influencing psoriasis development. Understanding this relationship may reveal new therapeutic strategies for treating psoriasis using MSCs.

Keywords:

biologics mesenchymal stem cells microenvironment psoriasis small molecules systemic treatments

More Related Videos

Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells

Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells

Published on: January 12, 2024

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

Related Experiment Videos

Last Updated: Aug 18, 2025

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells

Author Spotlight: Advancing Treatment Approaches with Adipose-Derived Stem Cells

Published on: January 12, 2024

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

Area of Science:

Immunology
Regenerative Medicine
Dermatology

Background:

Mesenchymal stem cells (MSCs) are multipotent stromal cells residing in various tissues.
MSC behavior is significantly modulated by their microenvironment, impacting regenerative and immunomodulatory functions.
The interplay between MSCs and inflammatory microenvironments is implicated in psoriasis pathogenesis.

Conclusions:

The psoriatic inflammatory milieu significantly impacts MSC homeostasis.
Targeting MSCs or their interaction with the microenvironment offers promising avenues for psoriasis therapy.