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Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
Progress on COVID-19 Chemotherapeutics Discovery and Novel Technology
Yalan Zhou1, Huizhen Wang1, Li Yang1
1Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Abstract:
COVID-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel highly contagious and pathogenic coronavirus that emerged in late 2019. SARS-CoV-2 spreads primarily through virus-containing droplets and small particles of air pollution, which greatly increases the risk of inhaling these virus particles when people are in close proximity. COVID-19 is spreading across the world, and the COVID-19 pandemic poses a threat to human health and public safety. To date, there are no specific vaccines or effective drugs against SARS-CoV-2. In this review, we focus on the enzyme targets of the virus and host that may be critical for the discovery of chemical compounds and natural products as antiviral drugs, and describe the development of potential antiviral drugs in the preclinical and clinical stages. At the same time, we summarize novel emerging technologies applied to the research on new drug development and the pathological mechanisms of COVID-19.
Insights
This review explores enzyme targets for developing new antiviral drugs against COVID-19 (coronavirus disease 2019). It covers preclinical and clinical drug development and emerging technologies for COVID-19 research.
Area of Science:
- Virology
- Infectious Diseases
- Drug Discovery
Background:
- COVID-19, caused by SARS-CoV-2, is a global pandemic with no specific vaccines or effective drugs.
- The virus spreads via respiratory droplets and airborne particles, posing significant public health risks.
Purpose of the Study:
- To review critical viral and host enzyme targets for developing chemical compounds and natural products as antiviral therapies.
- To summarize the current status of potential antiviral drug development in preclinical and clinical stages.
- To highlight novel technologies and pathological mechanisms relevant to COVID-19 drug research.
Main Methods:
- Literature review focusing on enzyme targets in SARS-CoV-2 infection.
- Analysis of preclinical and clinical studies on antiviral drug candidates.
- Synthesis of information on emerging technologies in drug development and disease pathology.
Main Results:
- Identified key viral and host enzymes as potential targets for antiviral drug discovery.
- Detailed the progress of various antiviral drug candidates through development stages.
- Outlined emerging technologies aiding in understanding COVID-19 and developing new treatments.
Conclusions:
- Targeting specific enzymes is crucial for effective antiviral drug development against COVID-19.
- A combination of drug development and technological innovation is essential to combat the pandemic.
- Further research into pathological mechanisms and novel therapeutic strategies is warranted.
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