High Throughput Fabrication of Flexible Top-Driven Sensing Probe

Area of Science:

• Biomedical Engineering
• Materials Science
• Medical Devices

Background:

• Current conservative and complicated traditional thrombosis treatment methods lack precision.
• Accurate localization of thrombosis in liquid flow environments is crucial for effective treatment.
• There is a need for advanced diagnostic tools for real-time thrombus detection.

Purpose of the Study:

• To propose a flexible intelligent probe (FIP) for accurate thrombosis localization.
• To develop a top-driven sensing strategy for FIP operation in liquid flow.
• To evaluate the FIP's performance in terms of sensing, mechanical properties, and control.

Main Methods:

• Fabrication of a flexible intelligent probe (FIP) with excellent electrical conductivity and mechanical properties.
• Implementation of a piezo-resistive sensing principle for flow velocity detection.
• Utilizing a magnetically driven method for probe manipulation and force application.

Main Results:

• The FIP exhibits quasi-linear sensitivity (approx. 0.325 L/min) in low flow velocity ranges (0-1 L/min).
• The magnetically driven FIP achieved a maximum deflection output force of 443.264 mN, a 43° maximum deflection angle, and a 54.176 mN maximum axial force.
• The FIP demonstrated accurate completion of command actions and effective real-time sensing feedback.

Conclusions:

• The developed flexible intelligent probe shows significant potential for precise thrombus localization.
• The FIP's piezo-resistive sensing and magnetic actuation enable effective real-time monitoring in liquid flow.
• This technology holds broad application prospects for thrombus detection and minimally invasive procedures.