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Acute Kidney Injury Among Patients with Multi-Drug Resistant Infection: A Study from Jordan

Ashraf O Oweis1, Heba N Zeyad1, Sameeha A Alshelleh2

  • 1Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan.

Journal of Multidisciplinary Healthcare
|December 12, 2022
PubMed
Abstract

Insights

Multidrug-resistant (MDR) infections significantly increase the risk of acute kidney injury (AKI) in hospitalized patients, leading to higher rates of hospitalization and mortality. Early detection and intervention are crucial to improve outcomes and reduce the burden of MDR infections.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) is a common complication in hospitalized patients, often associated with sepsis and infections.
  • Multidrug-resistant (MDR) infections represent a growing threat, potentially exacerbating AKI incidence and patient outcomes.

Purpose of the Study:

  • To evaluate the association between multidrug-resistant (MDR) infections and the incidence of acute kidney injury (AKI).
  • To assess the impact of MDR infections on hospitalization duration, need for dialysis, and mortality rates in patients with AKI.

Main Methods:

  • Retrospective study design analyzing data from adult patients with positive MDR cultures admitted to King Abdullah University Hospital (KAUH).
  • Review of medical records for 436 patients between January 2017 and December 2018, with at least one year of follow-up.

Main Results:

  • The incidence of AKI was 59.2% among patients with MDR infections. Key predictors of AKI included advanced age, hypertension, and chronic Foley catheter use.
  • Mortality rates were substantially higher in patients with AKI (74.4%) compared to those without AKI (44.4%).
  • Acinetobacter baumannii and Pseudomonas aeruginosa were the most frequently isolated MDR microorganisms.

Conclusions:

  • MDR infections are linked to high rates of AKI, prolonged hospitalization, and increased mortality.
  • Early detection and management of MDR infections are essential to mitigate adverse outcomes.
  • Public health initiatives promoting judicious antibiotic use are necessary to combat the rise of MDR infections.
Keywords:
acute kidney injuryinfectionmortalitymulti-drug resistant

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