Synthesis of Micro-/Nanohydroxyapatite Assisted by the Taylor-Couette Flow Reactor

Hydroxyapatite (HAP) has received increasing attention as an essential chemical product with good biocompatibility and adsorption properties. Generally, amorphous calcium phosphate (ACP) was generated first in the reactor and transformed into HAP after a period of crystallization. In this work, a series of Taylor-Couette flow reactors with different inner diameters were designed to assist in synthesizing HAP micro-/nanocrystals. ACP was obtained in a Taylor-Couette flow reactor at Re = 247 and successfully transformed into needle-like HAP crystals with a length of about 200 nm and a uniform particle size distribution after crystallization transformation. The yield of a single reactor can reach 2.16 kg per day. The finite element analysis results and time-space diagram of flow pattern variation showed that the Taylor-Couette flow reactor could improve the mixing behavior and the flow field distribution. The Taylor-Couette flow reactor provides a valuable reference for synthesizing inorganic micro-/nanomaterials.