Related Experiment Video
Updated: Aug 17, 2025

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
Apolipoproteins: New players in cancers
Yingcheng He1,2, Jianrui Chen1,2, Yanbing Ma1,2
1Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi, China.
Apolipoproteins (APOs), crucial for lipid metabolism, are increasingly recognized for their roles in cancer development and progression. This review explores APOs as potential cancer biomarkers and therapeutic targets.
Area of Science:
- Biochemistry
- Oncology
- Molecular Biology
Background:
- Apolipoproteins (APOs) are vital for lipid transport and metabolism.
- Their role in cancer has been historically under-explored compared to cardiovascular diseases.
- Recent research highlights APOs' involvement in tumorigenesis.
Purpose of the Study:
- To review the mechanisms of APOs in cancer development.
- To explore APOs as potential cancer biomarkers.
- To discuss APO-based anti-cancer therapies and genetic associations.
Main Methods:
- Literature review and synthesis of existing research on APOs and cancer.
- Analysis of studies on APOs' interaction with tumorigenesis pathways.
- Examination of data on APO dysregulation, genetic polymorphism, and therapeutic potential.
Main Results:
- APOs interact with classical cancer development pathways.
- APO dysregulation correlates with cancer occurrence and progression.
- APOs show promise as cancer biomarkers and therapeutic targets.
Conclusions:
- APOs play significant roles in various cancers.
- Understanding APO mechanisms offers new therapeutic strategies.
- Further research into APOs can advance cancer treatment.
More Related Videos
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
05:44Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
Published on: November 5, 2020
Related Concept Videos
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Prevention
Some...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...