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Related Experiment Video

Updated: Aug 17, 2025

Creating Objects and Object Categories for Studying Perception and Perceptual Learning

Creating Objects and Object Categories for Studying Perception and Perceptual Learning

Published on: November 2, 2012

Active inference, morphogenesis, and computational psychiatry.

Léo Pio-Lopez¹, Franz Kuchling¹, Angela Tung¹

¹Allen Discovery Center, Tufts University, Medford, MA, United States.

Frontiers in Computational Neuroscience

|December 12, 2022

Summary

This summary is machine-generated.

Active inference, a neuroscience theory, explains how cell development disorders mirror psychopathological conditions. Simulations and experiments in Xenopus embryos suggest novel regenerative medicine strategies by viewing morphogenesis as information processing.

Keywords:

Xenopus active inference computational psychiatry defect development morphogenesis

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Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Active inference models optimal behavior by coupling perception and action.
Morphogenesis is viewed as collective cell behavior solving problems in anatomical morphospace.
Psychopathological conditions are increasingly explained by disorders of active inference.

Purpose of the Study:

To link disorders of morphogenesis with disorders of active inference seen in psychopathology.
To simulate morphogenetic disorders using active inference principles.
To explore active inference's potential for understanding and treating developmental defects.

Main Methods:

Simulations of cellular behavior during morphogenesis using active inference models.
Analysis of aberrant active inference (e.g., sensory attenuation deficits, altered sensory precision).
Experimental validation in *Xenopus laevis* embryos using a dopamine antagonist (thioridazine).

Main Results:

Simulations demonstrated that aberrant active inference underlies developmental and morphogenetic disorders.
Reduced sensory attenuation and precision in cell collectives mimicked psychopathological conditions.
Thioridazine induced predicted developmental defects in *Xenopus laevis* embryos, supporting the model.

Conclusions:

Disorders of morphogenesis can be conceptualized as disorders of active inference.
Active inference provides a framework for understanding developmental defects as information processing issues.
This interdisciplinary approach may offer new avenues for regenerative medicine and evolutionary developmental biology.