Related Experiment Video
Updated: Aug 17, 2025

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
Published on: July 7, 2023
Role of High-Sensitivity C-Reactive Protein as a Biomarker and Endophenotype in Mania
Mohamed Abshad1, Basudeb Das1, Mahesh Kumar2
1Department of Psychiatry, Central Institute of Psychiatry, Ranchi, India.
Abstract:
To assess the role of high-sensitivity C-reactive protein (hs-CRP) as a biomarker, trait marker, and endophenotype in mania.
Abstract:
Forty patients with mania, 40 of their first-degree relatives, and 30 healthy controls were recruited via a purposive sampling method from May 2020 to February 2021. hs-CRP levels were measured in all groups at baseline. The patient group was evaluated with the Young Mania Rating Scale, and hs-CRP levels were assessed in all participants at baseline, 2 weeks, and 6 weeks. Data were analyzed with SPSS version 25.
Abstract:
hs-CRP levels were significantly higher in patients than in controls and first-degree relatives (P = .001). However, hs-CRP levels were not higher in first-degree relatives compared to healthy controls. There was a significant reduction in total YMRS and domain scores and hs-CRP levels in patients at weeks 2 and 6 compared to baseline (P = .02).
Abstract:
The blood hs-CRP level is a biomarker in mania, which may be a newer approach to detect disease progression and perhaps guide novel therapies. hs-CRP as an endophenotype requires further evaluation in future studies.
Related Concept Videos
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Mania and Antimanic Drugs: Overview
Bipolar Disorder
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Myocarditis II: Clinical Features and Diagnostic Tests

