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Updated: Aug 17, 2025
Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case
Sho Wako1, Ryotaro Ikeguchi1, Kunio Toda1
1Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
Abstract:
Although immune checkpoint inhibitors (ICIs) are widely used to treat unresectable malignant tumors, they can cause undesirable side effects called immune-related adverse events, including neurological toxicities. Here, we describe a case of ICI-related peripheral neuropathy (irPN) with characteristic cerebrospinal fluid (CSF) findings. In addition to pleocytosis and increased protein levels, the present case showed increased levels of CSF soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10, suggesting activated T cell-related autoimmunity. We believe that CSF cytokines and sIL-2R could be novel biomarkers of irPN.
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