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Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.8K

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Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines

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Managing Bone Health in Breast Cancer.

Ann E Kearns1

  • 1Division of Endocrinology, Mayo Clinic, Rochester, Minnesota.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|December 12, 2022
PubMed
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Estrogen deficiency can worsen osteoporosis. This review covers optimizing bone health during breast cancer endocrine therapy and using bone-modifying agents to prevent bone loss.

Keywords:
aromatase inhibitorbisphosphonatebreast cancerdenosumabestrogenosteoporosis

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Area of Science:

  • Oncology
  • Endocrinology
  • Bone Metabolism

Background:

  • Osteoporosis is frequently linked to estrogen deficiency.
  • Hormone receptor-positive breast cancer treatments can impact bone health.

Purpose of the Study:

  • To review bone health optimization in breast cancer patients undergoing adjuvant endocrine therapy.
  • To discuss antiresorptive agents for bone modification in breast cancer care.

Main Methods:

  • Narrative review of current literature.
  • Analysis of adjuvant endocrine treatments (tamoxifen, aromatase inhibitors).
  • Evaluation of antiresorptive agents (bisphosphonates, denosumab).

Main Results:

  • Endocrine therapies like tamoxifen and aromatase inhibitors affect bone density, varying by agent and menopausal status.
  • Bisphosphonates and denosumab mitigate bone loss associated with aromatase inhibitors.
  • Bisphosphonates show promise in reducing cancer relapse and improving survival in breast cancer patients.

Conclusions:

  • Understanding breast cancer treatments and their skeletal effects is crucial for bone health management.
  • Proactive bone health strategies are essential for women with breast cancer during and after treatment.