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Promising novel therapeutic targets for kidney disease: Emphasis on kidney-specific proteins

Tathambika Tejeswini Sen1, Ajinath Kale1, Maciej Lech2

  • 1Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India.

Drug Discovery Today
|December 12, 2022
PubMed

Insights

Discover promising new drug targets for kidney disease, including chronic kidney disease and acute kidney injury. Research highlights intermedin, Klotho, and sirtuin as potential therapeutic strategies for better patient outcomes.

Area of Science:

  • Nephrology
  • Pharmacology
  • Translational Medicine

Background:

  • Kidney disease affects 850 million people globally, with limited treatment options.
  • Preclinical research identifies numerous druggable targets for kidney disease.
  • Many potential therapeutic targets require further clinical validation.

Purpose of the Study:

  • To review promising candidate drug targets for chronic kidney disease (CKD) and acute kidney injury (AKI).
  • To identify novel therapeutic strategies for kidney disease attenuation.
  • To guide clinical development by considering target-related factors.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Identification and categorization of potential drug targets for CKD and AKI.
  • Analysis of target selection criteria for clinical development.

Main Results:

  • Promising CKD targets include intermedin, periostin, sirtuin, cannabinoid receptor, Klotho, and uromodulin.
  • Promising AKI targets include Apelin, Elabela, growth differentiation factor-15, Fyn kinase, and Klotho.
  • Klotho is identified as a target for both CKD and AKI.

Conclusions:

  • Several novel targets show potential for treating kidney diseases.
  • Clinical development should consider target redundancy, synergy with existing treatments, and cardiovascular effects.
  • Further research and clinical trials are needed to validate these targets for effective kidney disease therapies.
Keywords:
Acute kidney injuryChronic kidney diseaseExisting therapiesIntermedinKlothoNovel therapeutic targets

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