Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

EphA2 as an oncogenic driver: roles and mechanisms of action in cancer.

Molecular biology reports·2026

Same author

Human tissue-resident CD8 T cells contribute to trophoblast homeostasis in health and during acute inflammation.

bioRxiv : the preprint server for biology·2026

Same author

ERG orchestrates a dedifferentiation-senescence-inflammation triad in prostate cancer.

Molecular cancer research : MCR·2026

Same author

Rewiring dormancy.

Nature cell biology·2026

Same author

Benchmarking of local ancestry inference with different assays and parameters.

bioRxiv : the preprint server for biology·2026

Same author

Echo characterizes the desynchronization of gene expression and chromatin accessibility during cell-state transitions.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Aug 17, 2025

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

Defining cellular population dynamics at single-cell resolution during prostate cancer progression.

Alexandre A Germanos^1,2, Sonali Arora¹, Ye Zheng³

¹Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, United States.

|December 13, 2022

Summary

Advanced prostate cancer involves castration-resistant luminal cells driving progression. Inhibiting translation offers a potential therapeutic strategy against these aggressive tumors.

Keywords:

PTEN Single cell RNAseq cancer biology computational biology epithelial cells immune microenvironment mRNA Translation mouse prostate cancer systems biology

More Related Videos

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Related Experiment Videos

Last Updated: Aug 17, 2025

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Area of Science:

Oncology
Cell Biology
Cancer Research

Background:

Advanced prostate cancer is a major cause of male cancer deaths.
Understanding cellular drivers of prostate cancer progression is incomplete.
Castration resistance and tumor microenvironment are key to advanced disease.

Purpose of the Study:

Investigate prostate cancer cell dynamics from onset to androgen independence.
Identify cellular mechanisms driving treatment resistance and disease progression.
Explore therapeutic vulnerabilities in advanced prostate cancer.

Main Methods:

Utilized an in vivo murine model of prostate cancer.
Analyzed cellular dynamics at single-cell resolution.
Correlated findings with human patient data.

Main Results:

Observed expansion of castration-resistant intermediate luminal cells linked to poor prognosis.
Identified a pro-tumorigenic microenvironment created by epithelial cells and fibroblasts.
Discovered androgen-independent prostate cancer diversifies intermediate luminal cells.
Found distinct epithelial populations sensitive to translation inhibition.

Conclusions:

Castration-resistant luminal cells and immunosuppressive infiltrates dominate the tumor environment.
Translation inhibition induces epithelial cell death and reduces tumor heterogeneity.
Targeting translation may be a viable therapeutic strategy for advanced prostate cancer.