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[Gastroenteropancreatic neuroendocrine tumors : (GEP-NENs)]

Christian Sebesta1, Alexandra Feichter2, Flonza Selimi1

  • 12. Medizinische Abteilung für Hämatologie, Onkologie, Gastroenterologie, Hepatologie, Allgemeine Innere Medizin, Klinik Donaustadt, Langobardenstraße 122, 1220, Wien, Österreich.

Wiener Medizinische Wochenschrift (1946)
|December 13, 2022
PubMed

Insights

Neuroendocrine neoplasms (NENs) are diverse cancers needing a team approach. This review covers current diagnostics and treatments, noting surgery is an option even for metastatic G1/G2 NENs.

Area of Science:

  • Oncology
  • Medical Diagnostics
  • Therapeutics

Context:

  • Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of malignancies.
  • Patient management necessitates a multidisciplinary treatment strategy.
  • Current diagnostic and therapeutic approaches require a comprehensive overview.

Purpose:

  • To provide a concise review of the current state-of-the-art in diagnostics and therapy for NENs.
  • To highlight key treatment considerations for different NEN subgroups.
  • To emphasize the potential of nuclear medicine in NEN management.

Summary:

  • NENs are highly heterogeneous malignancies requiring a multidisciplinary approach.
  • Surgery is indicated for G1/G2 NENs, even in metastatic cases.
  • Guidelines and clinical studies are essential for subgroup-specific treatment details.
  • Nuclear medicine presents promising avenues for NEN diagnostics and therapy.

Impact:

  • Informs clinicians on current NEN diagnostic and therapeutic strategies.
  • Highlights the importance of a multidisciplinary approach in NEN patient care.
  • Underscores the need for further research into nuclear medicine applications for NENs.
Keywords:
CarcinoidGastrinomaInsulinomaMerkel-cell carcinomaMultiple endocrine neoplasia (MEN)Zollinger-Ellison syndrome

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