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TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression
Yue Zheng1,2,3,4, Yuheng Lang2,3,4,5, Bingcai Qi2,3,4,5
1School of Medicine, Nankai University, Tianjin, Binhai, China.
Abstract:
The migrasomes formation is mediated by the assembly of micron-scale tetraspanin macrodomains and the recruitment of tetraspanin 4 (TSPAN4). However, the physiological functions of TSPAN4 on migrasomes are less known. The TSPAN4 expression in macrophages in single-cell sequencing data, GEO datasets and TCGA database were determined. TSPAN4 expression was highly associated with atherosclerosis regression-related macrophages, intraplaque hemorrhage and ruptured plaques. TSPAN4 expression was upregulated in spontaneous MI and inducible MI mice model. Besides, TSPAN4 expression was highly correlated with tumor-associated macrophages. The study provided a critical role of TSPAN4 aberrant expression in the progression of atherosclerosis and pan-cancer, and the intervention of TSPAN4 and migrasomes may save dying patients' lives and improve their prognosis.
Insights
Tetraspanin 4 (TSPAN4) plays a key role in migrasome formation. Its aberrant expression is linked to atherosclerosis and cancer progression, suggesting potential therapeutic interventions.
Area of Science:
- Cell Biology
- Immunology
- Cardiovascular Research
Background:
- Migrasome formation involves tetraspanin macrodomains and tetraspanin 4 (TSPAN4).
- The precise physiological roles of TSPAN4 in migrasomes remain largely unexplored.
Purpose of the Study:
- To investigate the expression patterns and functional significance of TSPAN4 in macrophages.
- To explore the association of TSPAN4 with atherosclerosis and cancer progression.
Main Methods:
- Analysis of TSPAN4 expression in macrophages using single-cell sequencing, GEO datasets, and TCGA database.
- Evaluation of TSPAN4 upregulation in mouse models of myocardial infarction (MI).
- Correlation analysis of TSPAN4 expression with atherosclerosis markers and tumor-associated macrophages.
Main Results:
- TSPAN4 expression is significantly associated with atherosclerosis regression-related macrophages, intraplaque hemorrhage, and ruptured plaques.
- TSPAN4 is upregulated in both spontaneous and inducible mouse models of MI.
- Elevated TSPAN4 expression correlates strongly with tumor-associated macrophages.
Conclusions:
- Aberrant TSPAN4 expression is critically implicated in the progression of atherosclerosis and pan-cancer.
- Targeting TSPAN4 and migrasomes presents a potential therapeutic strategy to improve patient outcomes in cardiovascular diseases and cancer.
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