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Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine
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A rare cause of jejunal perforation: Monomorphic epitheliotropic intestinal T-cell lymphoma

Masahiro Yanagi1, Takuya Komura1, Takashi Kagaya1

  • 1Department of Gastroenterology National Hospital Organization Kanazawa Medical Center Kanazawa Japan.

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|December 14, 2022
PubMed

Insights

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare intestinal cancer. This case report details a fatal MEITL diagnosis complicated by jejunal perforation, highlighting the need for predictive methods and improved treatment strategies.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an exceptionally rare and aggressive form of T-cell lymphoma.
  • MEITL predominantly affects the jejunum and is associated with a high risk of intestinal perforation.

Observation:

  • This report details a fatal case of MEITL in a 79-year-old male patient.
  • The patient presented with jejunal perforation directly attributable to MEITL at the time of diagnosis.

Findings:

  • The patient underwent emergency surgery for the perforation but succumbed to prolonged peritonitis three months post-visit.
  • This case underscores the critical and often fatal complications associated with MEITL, particularly intestinal perforation.

Implications:

  • There is an urgent need to develop predictive tools to identify patients at risk of intestinal perforation from MEITL.
  • Systematizing treatment strategies is crucial to prevent perforation and improve outcomes for MEITL patients.
Keywords:
jejunummonomorphic epitheliotropic intestinal T‐cell lymphomaperforation

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