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Related Concept Videos

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Diseases of the Liver and Gallbladder

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Related Experiment Video

Updated: Aug 17, 2025

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
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Intrahepatic Splenosis: A Rare Case.

Mustafa Orhan Nalbant1

  • 1Department of Radiology, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey.

Current Medical Imaging
|December 14, 2022
PubMed
Summary

Splenosis is the ectopic autotransplantation of splenic tissue, often mimicking tumors. Considering patient history is key to diagnosing this rare condition, avoiding unnecessary surgery.

Keywords:
Diffusion-weighted imagesTc-99m-tagged heat-damaged RBC (Tc-99m-DRBC) scintigraphyintrahepatic splenosissplenectomysplenosis

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Area of Science:

  • Radiology
  • Abdominal Imaging
  • Surgical Pathology

Background:

  • Splenosis involves splenic tissue autotransplantation in ectopic locations, including intrahepatic sites, often misdiagnosed as neoplasms.
  • Distinguishing intrahepatic splenosis from liver tumors is challenging due to atypical radiological features.

Observation:

  • A 33-year-old female with a history of splenectomy and multiple surgeries presented with non-specific nodular liver lesions.
  • Imaging revealed scattered abdominal lesions, prompting consideration of splenosis in the differential diagnosis.

Findings:

  • Splenosis presents as hypoechoic to isoechoic masses on ultrasound and specific MRI signal intensities (low T1, iso-to-high T2).
  • Delayed phase imaging shows less signal intensity than liver parenchyma, and diffusion-weighted imaging reveals restricted diffusion (low ADC values).

Implications:

  • Splenosis diagnosis requires correlating imaging findings with patient history, particularly prior splenectomy or abdominal trauma.
  • Considering splenosis in the differential diagnosis can prevent misdiagnosis and unnecessary surgical interventions.