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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Nervous System: Ganglia and Nerves01:24

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Related Experiment Video

Updated: Aug 17, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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Electroneurological changes in peripheral nerves in patients post-COVID.

Jakub Stępień1,2, Żanna Pastuszak3,2

  • 1Insula Clinical Trials Center, Warsaw, Poland.

Journal of Neurophysiology
|December 14, 2022
PubMed
Summary

COVID-19 survivors often experience neurological issues, including post-COVID neuropathy. This study found significant neurophysiological abnormalities in peripheral nerves of survivors, persisting for at least six months after infection.

Keywords:
coronaviruselectroneurographynerve conduction studyneuropathypost-COVID-19 neuropathy

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Neurophysiology

Background:

  • Neurological manifestations affect approximately 36.4% of SARS-CoV-2 infected patients.
  • Post-COVID neuropathy is a recognized neurological complication of COVID-19.
  • Limited studies exist on neurophysiological abnormalities in the peripheral nerves of COVID-19 survivors.

Purpose of the Study:

  • To analyze changes in the peripheral nervous system of COVID-19 survivors.
  • To investigate neurophysiological abnormalities in COVID-19 survivors.

Main Methods:

  • A nerve conduction study (NCS) was performed on 45 COVID-19 survivors.
  • Results were compared to a control group of healthy individuals who underwent NCS prior to the pandemic.
  • Neurophysiological parameters of sensory and motor nerve fibers were analyzed.

Main Results:

  • Neurophysiological abnormalities were detected in both sensory and motor nerve fibers of COVID-19 survivors.
  • A significant reduction in the sensory action potential amplitude of the sural nerve was observed.
  • Abnormalities in amplitude and conduction velocity were most pronounced in both sensory and motor neurons in the arms and legs.
  • These nerve abnormalities persisted for up to 6 months post-COVID-19.

Conclusions:

  • COVID-19 infection can lead to persistent neurophysiological abnormalities in the peripheral nervous system.
  • Further research is needed to determine if SARS-CoV-2 directly damages peripheral nerves or if inflammatory responses are responsible.
  • Understanding the mechanisms of COVID-19-associated polyneuropathies is crucial.