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Exploring Cognitive Functions in Babies, Children & Adults with Near Infrared Spectroscopy
Published on: July 28, 2009
Oxygen-dependent functional brain haemodynamic response
Karolina Bejm1, Stanislaw Wojtkiewicz1, Zanna Pastuszak2
1Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
Abstract:
The influence of hypoxia - a condition where tissues are under oxygen deficiency - on the human brain under functional load has not been fully understood yet. This study aims to analyse the effects of hypoxia on the brain's haemodynamic response under visual stimulation, using the in-house developed functional near-infrared spectroscopy system and to quantify the hemodynamic response. Our results (median, 25th and 75th percentile) demonstrate the amplitude of the oxygenated haemoglobin functional response during hypoxia 0.30 µM (0.27, 0.41) was lower compared with the normoxia 0.63 µM (0.54, 0.93) and hyperoxia 0.73 µM (0.43, 1.09). No statistical significance is observed for the deoxygenated haemoglobin changes. The hypoxia has a statistically significant effect on the amplitude of the haemodynamic response (p < 0.001).
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